Systematic Study of Effects of Structural Modifications on the Aqueous Solubility of Drug-like Molecules
Author:
Affiliation:
1. Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States
Funder
Division of Graduate Education
National Institute of General Medical Sciences
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.6b00451
Reference20 articles.
1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
2. Prediction of drug solubility from structure
3. When poor solubility becomes an issue: From early stage to proof of concept
4. Deep understanding of structure–solubility relationship for a diverse set of organic compounds using matched molecular pairs
5. Improving Solubility via Structural Modification
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