Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7-Reference-Cited by-同舟云学术

Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7

Published:2016-04-26 Issue:6 Volume:7 Page:601-605
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Ren Chunyan¹,Smith Steven G.¹,Yap Kyoko¹,Li SiDe¹,Li Jiaojie¹²,Mezei Mihaly¹,Rodriguez Yoel¹³,Vincek Adam¹,Aguilo Francesca¹,Walsh Martin J.¹,Zhou Ming-Ming¹

Affiliation:

1. Department of Structural and Chemical Biology and ‡Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

2. Division of Liberal Arts and Sciences, Gist College, Gwangju Institute of Science & Technology, Buk-gu,Gwangju 61005, Republic of Korea

3. Department of Natural Sciences, Hostos Community College of City University of New York, Bronx, New York 10451, United States

Funder

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.6b00042

Reference25 articles.

1. Structure of HP1 Chromodomain Bound to a Lysine 9-Methylated Histone H3 Tail

2. Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9

3. Keeping it in the family: diverse histone recognition by conserved structural folds

4. The Polycomb complex PRC2 and its mark in life

5. Genome Regulation by Polycomb and Trithorax Proteins

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