Transdermal Bioavailability in Rats of Lidocaine in the Forms of Ionic Liquids, Salts, and Deep Eutectic

Author:

Berton Paula12,Di Bona Kristin R.13,Yancey Denise1,Rizvi Syed A. A.4,Gray Marquita3,Gurau Gabriela25,Shamshina Julia L.25,Rasco Jane F.3,Rogers Robin D.12ORCID

Affiliation:

1. Department of Chemistry, The University of Alabama, Tuscaloosa, Alabama 35487, United States

2. Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada

3. Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama 35487, United States

4. Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, Florida 33328, United States

5. 525 Solutions, Inc., 720 2nd Street, Tuscaloosa, Alabama 35401, United States

Funder

Howard Hughes Medical Institute

Canada Excellence Research Chairs, Government of Canada

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference18 articles.

1. Rogers, R. D., Daly, D. T., Swatloski, R. P., Hough, W. L., Davis, J. H., Jr., Smiglak, M., Pernak, J., and Spear, S. K.Multi-Functional Ionic Liquid Compositions for Overcoming Polymorphism and Imparting Improved Properties for Active Pharmaceutical, Biological, Nutritional, and Energetic Ingredients. US8232265 (2012); PCT/US2006/039454; WO 2007/044693 A2 (2007); MX 301158 (2012); CN 200680046195.7 (2013) .

2. Ionic Liquids Then and Now: From Solvents to Materials to Active Pharmaceutical Ingredients

3. Understanding the Effects of Ionicity in Salts, Solvates, Co-Crystals, Ionic Co-Crystals, and Ionic Liquids, Rather than Nomenclature, Is Critical to Understanding Their Behavior

4. Confused ionic liquid ions—a “liquification” and dosage strategy for pharmaceutically active salts

5. Liquid forms of pharmaceutical co-crystals: exploring the boundaries of salt formation

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