Development of Potent and Selective Janus Kinase 2/3 Directing PG–PROTACs

Author:

Alcock Lisa J.1,Chang Yunchao1,Jarusiewicz Jamie A.2,Actis Marisa2,Nithianantham Stanley2,Mayasundari Anand2,Min Jaeki2ORCID,Maxwell Dylan3,Hunt Jeremy3,Smart Brandon3,Yang Jun J.3,Nishiguchi Gisele2,Fischer Marcus24,Mullighan Charles G.15,Rankovic Zoran2ORCID

Affiliation:

1. Department of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, United States

2. Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, United States

3. Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, United States

4. Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, United States

5. Hematological Malignancies Program, St. Jude Comprehensive Cancer Center, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, United States

Funder

Snowdome Foundation

National Cancer Institute

American Lebanese Syrian Associated Charities

Leukemia and Lymphoma Society

National Institute of General Medical Sciences

St. Baldrick's Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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