Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell-Reference-Cited by-同舟云学术

Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell

Published:2021-06-02 Issue:7 Volume:12 Page:1093-1101
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Hayashi Kyohei¹^ORCID,Uehara Shota¹^ORCID,Yamamoto Shiho¹^ORCID,Cary Douglas R.²,Nishikawa Junichi²,Ueda Taichi¹,Ozasa Hiroki¹,Mihara Kousuke¹,Yoshimura Norito¹,Kawai Taeko¹,Ono Takashi¹,Yamamoto Saki¹,Fumoto Masataka¹,Mikamiyama Hidenori¹^ORCID

Affiliation:

1. Pharmaceutical Research Division, Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan

2. PeptiDream Inc., 3-25-23 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00134

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1. Substrate specificity of nicotinamide methyltransferase isolated from porcine liver

2. A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferase