A Comparative Assessment Study of Known Small-molecule GPVI Modulators

Author:

Foster Holly12ORCID,Wilson Clare2,Gauer Julia S.2,Xu Rui-Gang2,Howard Mark J.1,Manfield Iain W.3,Ariëns Robert2,Naseem Khalid2,Vidler Lewis R.4,Philippou Helen2,Foster Richard12ORCID

Affiliation:

1. School of Chemistry, University of Leeds, Leeds LS2 9JT, U.K.

2. Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), School of Medicine, University of Leeds, Leeds LS2 9JT, U.K.

3. Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K.

4. UCB, Slough, SL1 3WE, U.K.

Funder

British Heart Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference42 articles.

1. Heart Statistics─heart and Circulatory Diseases in the UK; British Heart Foundation, 2021; https://www.bhf.org.uk/what-we-do/our-research/heart-statistics (accessed 2021-02-09.

2. Heart and Stroke Statistics; American Heart Association, 2021; https://www.heart.org/en/about-us/heart-and-stroke-association-statistics (accessed 2021-05-21).

3. Elderly Bleeding Risk of Direct Oral Anticoagulants in Nonvalvular Atrial Fibrillation: A Systematic Review and Meta-Analysis of Cohort Studies

4. Real-world comparison of major bleeding risk among non-valvular atrial fibrillation patients initiated on apixaban, dabigatran, rivaroxaban, or warfarin

5. Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care

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