Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease-Reference-Cited by-同舟云学术

Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease

Published:2021-07-28 Issue:8 Volume:12 Page:1318-1324
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Turner Lewis D.¹^ORCID,Nielsen Alexander L.¹^ORCID,Lin Lucy¹^ORCID,Campedelli Antonio J.¹,Silvaggi Nicholas R.²^ORCID,Chen Jason S.³,Wakefield Amanda E.⁴^ORCID,Allen Karen N.²^ORCID,Janda Kim D.¹^ORCID

Affiliation:

1. Department of Chemistry, Scripps Research, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States

2. Department of Chemistry, Boston University, Boston, Massachusetts 02215, United States

3. Automated Synthesis Facility, Scripps Research, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States

4. Department of Biomedical Engineering and Department of Chemistry, Boston University, Boston, Massachusetts 02215, United States

Funder

National Institute of Allergy and Infectious Diseases

Natural Sciences and Engineering Research Council of Canada

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00325

Reference32 articles.

1. Phylogeny and taxonomy of the food-borne pathogen Clostridium botulinum and its neurotoxins

2. Botulism mortality in the USA, 1975-2009

3. Botulinum Toxin as a Biological Weapon

4. Evaluation of the Therapeutic Usefulness of Botulinum Neurotoxin B, C1, E, and F Compared with the Long Lasting Type A

5. Biowarfare, bioterrorism and biocrime: A historical overview on microbial harmful applications

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3. Transformation of a Metal Chelate into a “Catch and Anchor” Inhibitor of Botulinum A Protease;International Journal of Molecular Sciences;2023-02-21

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