Synthesis of Deuterated Heterocycles with Me<sub>2</sub>NCD(OMe)<sub>2</sub> and Evaluation of the Products for Metabolism by Aldehyde Oxidase-Reference-Cited by-同舟云学术

Synthesis of Deuterated Heterocycles with Me₂NCD(OMe)₂ and Evaluation of the Products for Metabolism by Aldehyde Oxidase

Published:2022-01-21 Issue:2 Volume:13 Page:250-256
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Choi Chulho¹^ORCID,Carlo Anthony A.²,Cronin Ciarán N.²,Jing Konghua³,Kung Daniel W.¹^ORCID,Liu Jianhua²,Lombardo Vincent M.¹,Turco Abigail R.¹,Yin Juxing³,Yu Aijia³,Wright Stephen W.¹

Affiliation:

1. Medicine Design, Pfizer Worldwide Research, Development and Medical, Eastern Point Road, Groton, Connecticut 06340, United States

2. Structural Biology and Protein Sciences, Pfizer Worldwide Research, Development and Medical, La Jolla, California 92121, United States

3. WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00634

Reference28 articles.

1. Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

2. Systematic Structure Modifications of Imidazo[1,2-a]pyrimidine to Reduce Metabolism Mediated by Aldehyde Oxidase (AO)

3. Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs

4. Applications of Deuterium in Medicinal Chemistry

5. Aldehyde Oxidase Metabolism in Drug Discovery

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