Increased Molecular Flexibility Widens the Gap between Ki and Kd values in Screening for Retinoid X Receptor Modulators-Reference-Cited by-同舟云学术

Increased Molecular Flexibility Widens the Gap between K_i and K_d values in Screening for Retinoid X Receptor Modulators

Published:2022-01-21 Issue:2 Volume:13 Page:211-217
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Watanabe Masaki¹^ORCID,Nakamura-Nakayama Mariko¹,Fujihara Michiko¹²,Kawasaki Mayu³,Nakano Shogo³^ORCID,Kakuta Hiroki¹^ORCID

Affiliation:

1. Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan

2. AIBIOS K.K., Tri-Seven Roppongi 8F, 7-7-7 Roppongi, Minato-ku, Tokyo 106-0032, Japan

3. Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan

Funder

Tokyo Biochemical Research Foundation

Okayama Foundation for Science and Technology

Kobayashi Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00575

Reference44 articles.

1. Current Screening Methodologies in Drug Discovery for Selected Human Diseases

2. The utility of target-based discovery

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5. Screening for PPAR Non-Agonist Ligands Followed by Characterization of a Hit, AM-879, with Additional No-Adipogenic and cdk5-Mediated Phosphorylation Inhibition Properties

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