Lead Optimization: Synthesis and Biological Evaluation of PBT-1 Derivatives as Novel Antitumor Agents-Reference-Cited by-同舟云学术

Lead Optimization: Synthesis and Biological Evaluation of PBT-1 Derivatives as Novel Antitumor Agents

Published:2021-11-17 Issue:12 Volume:12 Page:1948-1954
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Xie Lan¹^ORCID,Goto Masuo¹^ORCID,Chen Xiaoyan¹,Morris-Natschke Susan L.¹,Lee Kuo-Hsiung¹^ORCID

Affiliation:

1. Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States

Funder

National Cancer Institute

Eshelman Institute for Innovation, University of North Carolina

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00505

Reference22 articles.

1. An antimicrobial alkaloid fromFicus septica

2. Phenanthroindolizidine Alkaloids as Cytotoxic Substances in a Danaid Butterfly, Ideopsis similis, against Human Cancer Cells

3. In Vitro Cytotoxic Activity of Phenanthroindolizidine Alkaloids from Cynanchum vincetoxicum and Tylophora tanakae against Drug-Sensitive and Multidrug-Resistant Cancer Cells

4. Anti-Inflammatory Mechanisms of Phenanthroindolizidine Alkaloids

5. Effects of a novel tylophorine analog on collagen-induced arthritis through inhibition of the innate immune response

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