Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors-Reference-Cited by-同舟云学术

Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors

Published:2021-06-22 Issue:7 Volume:12 Page:1108-1115
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Tong Yunsong¹^ORCID,Florjancic Alan S.²,Clark Rick F.²,Lai Chunqiu²,Mastracchio Anthony²^ORCID,Zhu Gui-dong²,Smith Morey L.²,Kovar Peter J.³,Shaw Bailin²,Albert Daniel H.²,Qiu Wei⁴,Longenecker Kenton L.⁴,Liu Xiaoqin⁵,Olson Amanda M.⁵,Osterling Donald J.⁵,Tahir Stephen K.²,Phillips Darren C.²,Leverson Joel D.²,Souers Andrew J.²,Penning Thomas D.²^ORCID

Affiliation:

1. Drug Discovery Science & Technology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States

2. Oncology Discovery, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States

3. High Throughput Biology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States

4. Structural Biology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States

5. Pharmacology, Abbvie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States

Funder

AbbVie

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00161

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