Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis-Reference-Cited by-同舟云学术

Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis

Published:2021-04-30 Issue:5 Volume:12 Page:827-835
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Liu Qingjie¹^ORCID,Xiao Hai-Yun¹,Batt Douglas G.¹,Xiao Zili¹,Zhu Yeheng¹,Yang Michael G.¹^ORCID,Li Ning¹,Yip Shiuhang¹,Li Peng¹,Sun Dawn¹,Wu Dauh-Rurng¹,Ruzanov Max¹,Sack John S.¹,Weigelt Carolyn A.¹,Wang Jinhong¹,Li Sha¹,Shuster David J.¹,Xie Jenny H.¹,Song Yunling¹,Sherry Tara¹,Obermeier Mary T.¹,Fura Aberra¹,Stefanski Kevin¹,Cornelius Georgia¹,Chacko Silvi¹,Khandelwal Purnima¹,Dudhgaonkar Shailesh²,Rudra Anjuman²,Nagar Jignesh²,Murali Venkata²,Govindarajan Arun²,Denton Rex¹,Zhao Qihong¹,Meanwell Nicholas A.¹^ORCID,Borzilleri Robert¹,Dhar T. G. Murali¹^ORCID

Affiliation:

1. Research and Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08540-4000, United States

2. Biocon Bristol Myers Squibb Research Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bengaluru 560099, India

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00112

Reference27 articles.

1. Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism

2. The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells