Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an <i>In Vivo</i> Efficacious TLR7/8 Antagonist-Reference-Cited by-同舟云学术

Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist

Published:2022-03-10 Issue:4 Volume:13 Page:658-664
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Betschart Claudia¹^ORCID,Faller Michael²,Zink Florence²,Hemmig René²,Blank Jutta²,Vangrevelinghe Eric¹,Bourrel Marjorie¹,Glatthar Ralf¹,Behnke Dirk¹,Barker Kerstin¹,Heizmann Andreas¹,Angst Daniela¹^ORCID,Nimsgern Pierre¹,Jacquier Sébastien¹,Junt Tobias³,Zipfel Géraldine³,Ruzzante Giulia³,Loetscher Pius³,Limonta Sarah³,Hawtin Stuart³,Andre Cedric Bernard³,Boulay Thomas³,Feifel Roland⁴,Knoepfel Thomas¹^ORCID

Affiliation:

1. Global Discovery Chemistry, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland

2. Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland

3. Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland

4. Pharmacokinetic Sciences, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00696

Reference27 articles.

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