Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors-Reference-Cited by-同舟云学术

Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors

Published:2021-11-02 Issue:11 Volume:12 Page:1794-1801
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Martínez-González Sonia¹,Alvarez Rosa M.¹,Martín José I.¹,García Ana Belén¹,Riesco-Fagundo Concepción¹,Varela Carmen¹^ORCID,Rodríguez Hergueta Antonio¹,González Cantalapiedra Esther¹,Albarrán M. I.¹,Gómez-Casero Elena¹,Cebriá Antonio¹,Aguirre Enara¹,Ajenjo Nuria¹,Cebrián David¹,Di Geronimo Bruno¹,Cunningham Darren²,O’Neill Michael²,Dave Harish P. G.³,Blanco-Aparicio Carmen¹,Pastor Joaquín¹

Affiliation:

1. Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, E-28029 Madrid, Spain

2. Inflection Biosciences Ltd., Suite 15, Anglesea 419 House, Carysfort Avenue Blackrock, Dublin A94 VC59, Ireland

3. AUM Biosciences, 24-428 16A, 10 Anson Road, International Plaza, Singapore 429 079903

Funder

Ministerio de Ciencia e Innovaci??n

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00412

Reference38 articles.

1. Targeting PI3K in cancer: mechanisms and advances in clinical trials

2. From Cortellis Intelligence of Clarivate.

3. Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway Inhibitors

4. Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

5. The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes

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