Ring Size as an Independent Variable in Cyclooligomeric Depsipeptide Antiarrhythmic Activity
Author:
Affiliation:
1. Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States
2. Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37235, United States
Funder
National Heart, Lung, and Blood Institute
Pharmaceutical Research and Manufacturers of America Foundation
National Science Foundation
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00508
Reference44 articles.
1. Cyclic Peptides as Drugs for Intracellular Targets: The Next Frontier in Peptide Therapeutic Development
2. Structure-Based Macrocycle Design in Small-Molecule Drug Discovery and Simple Metrics To Identify Opportunities for Macrocyclization of Small-Molecule Ligands
3. Overview of Macrocycles in Clinical Development and Clinically Used
4. N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions
5. An Evaluation of Peptide-Bond Isosteres
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