Malaria Box-Inspired Discovery of <i>N</i>-Aminoalkyl-β-carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials-Reference-Cited by-同舟云学术

Malaria Box-Inspired Discovery of N-Aminoalkyl-β-carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials

Published:2022-02-23 Issue:3 Volume:13 Page:365-370
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Mathew Jopaul¹,Ding Sha¹,Kunz Kevin A.¹,Stacy Emily E.¹,Butler Joshua H.²,Haney Reagan S.²,Merino Emilio F.²,Butschek Grant J.²,Rizopoulos Zaira³,Totrov Maxim⁴,Cassera Maria B.²^ORCID,Carlier Paul R.¹^ORCID

Affiliation:

1. Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States

2. Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 Green Street, Athens, Georgia 30602, United States

3. Medicines for Malaria Venture, 1215 Geneva, Switzerland

4. Molsoft LLC, 11999 Sorrento Valley Road, San Diego, California 92121, United States

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00663

Reference15 articles.

1. World Malaria Report 2021. The World Health Organization, available at https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2021 (accessed 2021-12-13).

2. Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis as Antimalarial Drugs

3. Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum

4. The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

5. Antiapicoplast and Gametocytocidal Screening To Identify the Mechanisms of Action of Compounds within the Malaria Box

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