A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists-Reference-Cited by-同舟云学术

A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists

Published:2021-07-19 Issue:8 Volume:12 Page:1230-1237
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Villemure Elisia¹^ORCID,Terrett Jack A.¹^ORCID,Larouche-Gauthier Robin²,Déry Martin²,Chen Huifen¹^ORCID,Reese Rebecca M.³,Shields Shannon D.³^ORCID,Chen Jun⁴,Magnuson Steven¹,Volgraf Matthew¹

Affiliation:

1. Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Paraza Pharma, Inc. 2525 Avenue Marie-Curie, Montréal, Québec H4S 2E1, Canada

3. Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

4. Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00305

Reference26 articles.

1. Membrane protein structural biology in the era of single particle cryo-EM

2. New approaches towards the understanding of integral membrane proteins: A structural perspective on G protein-coupled receptors

3. An outlook on using serial femtosecond crystallography in drug discovery

4. High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875

5. Structural identification of a hotspot on CFTR for potentiation

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