N-Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors-Reference-Cited by-同舟云学术

N-Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors

Published:2021-09-21 Issue:10 Volume:12 Page:1546-1552
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Feng Yangbo¹²^ORCID,Park HaJeung³,Ryu Jae Cheon⁴,Yoon Sung OK⁴

Affiliation:

1. Reaction Biology Corporation, One Great Valley Parkway, Malvern, Pennsylvania 19355, United States

2. Department of Molecular and Cellular Pharmacology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33136, United States

3. Crystallography Core Facility, Scripps Research, 130 Scripps Way, Jupiter, Florida 33458, United States;

4. Department of Biological Chemistry & Pharmacology, Ohio State University College of Medicine, Columbus, Ohio 43210, United States;

Funder

Alzheimer's Drug Discovery Foundation

National Institute on Aging

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00334

Reference36 articles.

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3. Nocodazole-induced p53-dependent c-Jun N-terminal Kinase Activation Reduces Apoptosis in Human Colon Carcinoma HCT116 Cells

4. Effect of PI3K/Akt/mTOR signaling pathway on JNK3 in Parkinsonian rats

5. Small Peptide Inhibitor of JNK3 Protects Dopaminergic Neurons from MPTP Induced Injury via Inhibiting the ASK1-JNK3 Signaling Pathway

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