Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis
Author:
Affiliation:
1. Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00134
Reference31 articles.
1. PKC and the control of localized signal dynamics
2. PKC-θ function at the immunological synapse: prospects for therapeutic targeting
3. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
4. Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells
5. Differential Regulation of Th2 and Th1 Lung Inflammatory Responses by Protein Kinase Cθ
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