Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis-Reference-Cited by-同舟云学术

Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis

Published:2019-06-27 Issue:8 Volume:10 Page:1134-1139
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Collier Philip N.¹^ORCID,Twin Heather C.,Knegtel Ronald M. A.^ORCID,Boyall Dean,Brenchley Guy,Davis Christopher J.,Keily Shazia,Mak Chau,Miller Andrew,Pierard Françoise,Settimo Luca,Bolton Clare M.,Chiu Peter,Curnock Adam,Doyle Elisabeth¹,Tanner Adam J.,Jimenez Juan-Miguel

Affiliation:

1. Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00134

Reference31 articles.

1. PKC and the control of localized signal dynamics

2. PKC-θ function at the immunological synapse: prospects for therapeutic targeting

3. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

4. Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells

5. Differential Regulation of Th2 and Th1 Lung Inflammatory Responses by Protein Kinase Cθ

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