Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists-Reference-Cited by-同舟云学术

Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists

Published:2019-02-26 Issue:3 Volume:10 Page:367-373
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Duan James J.-W.¹^ORCID,Lu Zhonghui¹,Jiang Bin¹,Stachura Sylwia¹,Weigelt Carolyn A.¹,Sack John S.¹,Khan Javed¹,Ruzanov Max¹,Galella Michael A.¹,Wu Dauh-Rurng¹,Yarde Melissa¹,Shen Ding-Ren¹,Shuster David J.¹,Borowski Virna¹,Xie Jenny H.¹,Zhang Lisa¹,Vanteru Sridhar²,Gupta Arun Kumar²,Mathur Arvind¹,Zhao Qihong¹,Foster William¹,Salter-Cid Luisa M.¹,Carter Percy H.¹^ORCID,Dhar T. G. Murali¹^ORCID

Affiliation:

1. Research and Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

2. Bristol-Myers Squibb-Biocon Research Center, Bangalore 560099, India

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00010

Reference19 articles.

1. Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism

2. The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells