Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8S Configuration-Reference-Cited by-同舟云学术

Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8S Configuration

Published:2020-01-02 Issue:2 Volume:11 Page:108-113
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Johnson Tyler A.¹²^ORCID,Morris Joseph D.¹,Coppage David A.²,Cook Colon V.¹,Persi Lauren N.¹,Ogarrio Marcos A.¹,Garcia Taylor C.¹,McIntosh Nicole L.¹,McCauley Erin P.²,Media Joseph³,Maheshwari Mani³,Valeriote Frederick A.³,Shaw Jiajiu⁴,Crews Phillip²^ORCID

Affiliation:

1. Department of Natural Sciences & Mathematics, Dominican University of California, San Rafael, California 94901, United States

2. Department of Chemistry & Biochemistry, University of California, Santa Cruz, Santa Cruz, California 95064, United States

3. Josephine Ford Cancer Center, Division of Hematology and Oncology, Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan 48202, United States

4. 21st Century Therapeutics, 440 Burroughs, Suite 447, Detroit, Michigan 48202, United States

Funder

National Cancer Institute

Dominican University of California

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00302

Reference27 articles.

1. Mycothiazole, a polyketide heterocycle from a marine sponge