Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing-Reference-Cited by-同舟云学术

Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing

Published:2019-10-18 Issue:11 Volume:10 Page:1537-1542
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Lewis Timothy A.¹^ORCID,de Waal Luc¹²,Wu Xiaoyun¹²,Youngsaye Willmen¹,Wengner Antje³,Kopitz Charlotte³,Lange Martin³,Gradl Stefan³,Ellermann Manuel³,Lienau Philip³,Schreiber Stuart L.¹^ORCID,Greulich Heidi¹²,Meyerson Matthew¹²

Affiliation:

1. Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States

2. Dana-Farber Cancer Institute, Boston, Massachusetts 01255, United States

3. Bayer AG, Berlin, Germany

Funder

Bayer

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00360

Reference15 articles.

1. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics

2. Expression and regulation of Schlafen (SLFN) family members in primary human monocytes, monocyte-derived dendritic cells and T cells

3. Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST)

4. Targeting tumor cells based on Phosphodiesterase 3A expression

5. The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig

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