Synthesis and Antiproliferative Activity of Nitric Oxide-Donor Largazole Prodrugs-Reference-Cited by-同舟云学术

Synthesis and Antiproliferative Activity of Nitric Oxide-Donor Largazole Prodrugs

Published:2020-02-07 Issue:5 Volume:11 Page:846-851
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Borgini Matteo¹,Zamperini Claudio¹²,Poggialini Federica¹,Ferrante Luca³,Summa Vincenzo⁴,Botta Maurizio¹²⁵^ORCID,Fabio Romano Di³⁴^ORCID

Affiliation:

1. Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy

2. Lead Discovery Siena S.r.l., Castelnuovo Berardenga, 53019 Siena, Italy

3. Promidis, Via Olgettina 60, 20132 Milano, Italy

4. IRBM Science Park, Via Pontina Km 30.600, 00070 Pomezia, Italy

5. Biotechnology College of Science and Technology, Temple University, BioLife Science Building, Suite 333, 1900 North 12th Street, Philadelphia, Pennsylvania 19122, United States

Funder

Collezione Nazionale dei Composti Chimici e Centro Screening

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00643

Reference39 articles.

1. Structure and Activity of Largazole, a Potent Antiproliferative Agent from the Floridian Marine Cyanobacterium Symploca sp.

2. Largazole Pharmacokinetics in Rats by LC-MS/MS

3. Largazole: From discovery to broad-spectrum therapy

4. Total Synthesis and Molecular Target of Largazole, a Histone Deacetylase Inhibitor

5. Advances and Challenges of HDAC Inhibitors in Cancer Therapeutics

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