Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads-Reference-Cited by-同舟云学术

Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads

Published:2019-07-02 Issue:8 Volume:10 Page:1159-1165
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Oehlrich Daniel^ORCID,Peschiulli Aldo,Tresadern Gary^ORCID,Van Gool Michiel¹,Vega Juan Antonio¹,De Lucas Ana Isabel¹,Alonso de Diego Sergio A.¹,Prokopcova Hana,Austin Nigel,Van Brandt Sven,Surkyn Michel,De Cleyn Michel,Vos Ann,Rombouts Frederik J. R.^ORCID,Macdonald Gregor,Moechars Dieder,Gijsen Harrie J. M.^ORCID,Trabanco Andrés A.¹^ORCID

Affiliation:

1. Discovery Sciences Medicinal Chemistry, Janssen Research & Development, Janssen−Cilag S.A., C/Jarama 75A, 45007 Toledo, Spain

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00181

Reference22 articles.

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5. Efficacy and Safety Trial of Verubecestat (MK-8931) in Participants With Prodromal Alzheimer's Disease (MK-8931-019) (APECS). ClinicalTrials.gov; U.S. National Library of Medicine, 2013. https://clinicaltrials.gov/ct2/show/NCT01953601.

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