Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains-Reference-Cited by-同舟云学术

Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains

Published:2019-11-22 Issue:12 Volume:10 Page:1648-1654
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Johnson Jorden A.¹,Nicolaou Christos A.²^ORCID,Kirberger Steven E.¹,Pandey Anil K.¹,Hu Haitao²,Pomerantz William C. K.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States

2. Discovery Chemistry Research & Technologies, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States

Funder

National Institute of General Medical Sciences

Lilly Research Award Program

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00414

Reference26 articles.

1. Fragment-based lead discovery grows up

2. Fragment screening to predict druggability (ligandability) and lead discovery success

3. Druggability Indices for Protein Targets Derived from NMR-Based Screening Data

4. Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

5. Property Distributions: Differences between Drugs, Natural Products, and Molecules from Combinatorial Chemistry

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