New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase-Reference-Cited by-同舟云学术

New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase

Published:2020-07-30 Issue:8 Volume:11 Page:1645-1652
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Tanaka Yuta¹^ORCID,Kurasawa Osamu¹,Yokota Akihiro¹,Klein Michael G.²,Saito Bunnai¹,Matsumoto Shigemitsu¹,Okaniwa Masanori¹,Ambrus-Aikelin Geza²,Uchiyama Noriko¹,Morishita Daisuke¹,Kimura Hiromichi¹,Imamura Shinichi¹

Affiliation:

1. Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan

2. Department of Structural Biology, Takeda California, 10410 Science Center Drive, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00331

Reference22 articles.

1. Hypusine, a polyamine-derived amino acid critical for eukaryotic translation

2. Eukaryotic translation initiation factor (eIF) 5A stimulates protein synthesis in Saccharomyces cerevisiae

3. Hypusine-containing protein eIF5A promotes translation elongation

4. Oncogenic Role ofeIF-5A2in the Development of Ovarian Cancer

5. Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells

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