Discovery of a Highly Selective and Potent TRPC3 Inhibitor with High Metabolic Stability and Low Toxicity-Reference-Cited by-同舟云学术

Discovery of a Highly Selective and Potent TRPC3 Inhibitor with High Metabolic Stability and Low Toxicity

Published:2021-03-05 Issue:4 Volume:12 Page:572-578
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Zhang Sicheng¹^ORCID,Romero Luis O.²³,Deng Shanshan¹,Wang Jiaxing¹,Li Yong⁴,Yang Lei⁴,Hamilton David J.⁵,Miller Duane D.¹^ORCID,Liao Francesca-Fang⁶,Cordero-Morales Julio F.²,Wu Zhongzhi¹,Li Wei¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, the University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States

2. Department of Physiology, the University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States

3. Integrated Biomedical Sciences Graduate Program, College of Graduate Health Sciences, Memphis, Tennessee 38163, United States

4. Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, United States

5. Department of Comparative Medicine, College of Graduate Health Sciences, the University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States

6. Department of Pharmacology, Addiction Science, and Toxicology, the University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States

Funder

University of Tennessee Health Science Center

National Institute on Aging

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00571

Reference25 articles.

1. TRP Channels