ONO-8430506: A Novel Autotaxin Inhibitor That Enhances the Antitumor Effect of Paclitaxel in a Breast Cancer Model-Reference-Cited by-同舟云学术

ONO-8430506: A Novel Autotaxin Inhibitor That Enhances the Antitumor Effect of Paclitaxel in a Breast Cancer Model

Published:2020-05-14 Issue:6 Volume:11 Page:1335-1341
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Iwaki Yuzo^ORCID,Ohhata Akira,Nakatani Shingo,Hisaichi Katsuya,Okabe Yasuyuki,Hiramatsu Atsushi,Watanabe Toshihide,Yamamoto Shingo,Nishiyama Taihei,Kobayashi Juta,Hirooka Yasuo,Moriguchi Hideki,Maeda Tatsuo,Katoh Makoto,Komichi Yuka,Ota Hiroto,Matsumura Naoya,Okada Masahiro,Sugiyama Tetsuya,Saga Hiroshi,Imagawa Akira

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00200

Reference21 articles.

1. Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein.

2. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

3. Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase

4. cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases.

5. Autotaxin Stabilizes Blood Vessels and Is Required for Embryonic Vasculature by Producing Lysophosphatidic Acid

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