Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity-Reference-Cited by-同舟云学术

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Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity

Published:2020-07-15 Issue:10 Volume:11 Page:2017-2023
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Uda Junichiro¹^ORCID,Kobashi Seiichi¹,Miyata Sachiho¹,Ashizawa Naoki²,Matsumoto Koji²,Iwanaga Takashi²

Affiliation:

1. Research Laboratories 1, Medical R&D Division, Fuji Yakuhin Co., Ltd., 1-32-3, Nishiomiya, Nishi-ku, Saitama-shi, Saitama 331-0078, Japan

2. Research Laboratories 2, Medical R&D Division, Fuji Yakuhin Co., Ltd., 636-1, Iidashinden, Nishi-ku, Saitama-shi, Saitama 331-0068, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00176

Reference35 articles.

1. Physiology of Hyperuricemia and Urate-Lowering Treatments

2. Uric Acid as a Cardiometabolic Risk Factor: To Be or Not to Be

3. Regulation of Uric Acid Excretion by the Kidney

4. New medications in development for the treatment of hyperuricemia of gout

5. Evidence for a Postsecretory Reabsorptive Site for Uric Acid in Man

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1. Transport mechanism and structural pharmacology of human urate transporter URAT1;Cell Research;2024-09-09

2. Role of Transporters in Hyperuricemia;Physiology;2024-05-22

3. Unique Binding Sites of Uricosuric Agent Dotinurad for Selective Inhibition of Renal Uric Acid Reabsorptive Transporter URAT1;Journal of Pharmacology and Experimental Therapeutics;2024-04-26

4. Proline-derived quinoline formamide compounds as human urate transporter 1 inhibitors with potent uric acid-lowering activities;European Journal of Medicinal Chemistry;2024-04

5. Virtual screening and biological evaluation of natural products as urate transporter 1 (URAT1) inhibitors;Journal of Biomolecular Structure and Dynamics;2024-03-29

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