Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity
Author:
Affiliation:
1. Paraza Pharma Inc., 2525 Ave. Marie-Curie, Montreal, QC, Canada H4S 2E1
2. Genentech Inc., 1 DNA Way, South San Francisco, California 94080-4990, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00344
Reference26 articles.
1. The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2. Targeting the unfolded protein response for disease intervention
3. Proteostasis control by the unfolded protein response
4. Targeting the unfolded protein response in disease
5. Gr(i)p the ER to Stress Out Melanoma
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