Bridgehead Modifications of Englerin A Reduce TRPC4 Activity and Intravenous Toxicity but not Cell Growth Inhibition-Reference-Cited by-同舟云学术

Bridgehead Modifications of Englerin A Reduce TRPC4 Activity and Intravenous Toxicity but not Cell Growth Inhibition

Published:2020-08-03 Issue:9 Volume:11 Page:1711-1716
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Wu Zhenhua¹,Suppo Jean-Simon²,Tumova Sarka³,Strope Jonathan⁴,Bravo Fernando²,Moy Melody¹,Weinstein Ethan S.¹^ORCID,Peer Cody J.⁴,Figg William D.⁴,Chain William J.¹^ORCID,Echavarren Antonio M.²,Beech David J.³,Beutler John A.⁵^ORCID

Affiliation:

1. Department of Chemistry & Biochemistry, University of Delaware, 163 The Green, Newark, Delaware 19716, United States

2. Institute of Chemical Research of Catalonia (ICIQ), 43007 Tarragona, Spain

3. School of Medicine, University of Leeds, Leeds LS2 9JT, U.K.

4. Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, United States

5. Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States

Funder

National Cancer Institute

Medical Research Council

Ministerio de Econom?a, Industria y Competitividad, Gobierno de Espa?a

European Regional Development Fund

University of Delaware

Ag?ncia de Gesti? d'Ajuts Universitaris i de Recerca

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00186

Reference36 articles.

1. Englerin A, a Selective Inhibitor of Renal Cancer Cell Growth, from Phyllanthus engleri

2. Total Synthesis and Absolute Configuration of the Guaiane Sesquiterpene Englerin A

3. Enantioselective Synthesis of (−)-Englerins A and B

4. Enantioselective Formal Synthesis of (−)-Englerin A via a Rh-Catalyzed [4 + 3] Cycloaddition Reaction

5. Asymmetric, Protecting-Group-Free Total Synthesis of (−)-Englerin A

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