Discovery of PIPE-359, a Brain-Penetrant, Selective M1 Receptor Antagonist with Robust Efficacy in Murine MOG-EAE-Reference-Cited by-同舟云学术

Discovery of PIPE-359, a Brain-Penetrant, Selective M1 Receptor Antagonist with Robust Efficacy in Murine MOG-EAE

Published:2020-12-24 Issue:1 Volume:12 Page:155-161
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Schrader Thomas O.¹^ORCID,Xiong Yifeng¹,Lorenzana Ariana O.¹,Broadhead Alexander¹,Stebbins Karin J.¹,Poon Michael M.¹,Baccei Christopher¹,Lorrain Daniel S.¹

Affiliation:

1. Pipeline Therapeutics, 10578 Science Center Drive, Suite 200, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00626

Reference28 articles.

1. Multiple Sclerosis

2. Multiple Sclerosis — The Plaque and Its Pathogenesis

3. The prevalence of MS in the United States

4. Advances in the Treatment of Multiple Sclerosis

5. Immunological Aspects of Approved MS Therapeutics

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, Synthesis, and Biological Evaluation of 4,4’-Difluorobenzhydrol Carbamates as Selective M1 Antagonists;Pharmaceuticals;2022-02-18

2. Potential Role for Combined Subtype-Selective Targeting of M1 and M3 Muscarinic Receptors in Gastrointestinal and Liver Diseases;Frontiers in Pharmacology;2021-11-04

3. Remyelination: what are the prospects for regenerative therapies in multiple sclerosis?;Emerging Topics in Life Sciences;2021-08-20

4. Vinyl sulfone synthesis via copper-catalyzed three-component decarboxylative addition;Organic & Biomolecular Chemistry;2021