Synthesis of HDAC Inhibitor Libraries via Microscale Workflow-Reference-Cited by-同舟云学术

Synthesis of HDAC Inhibitor Libraries via Microscale Workflow

Published:2021-02-08 Issue:3 Volume:12 Page:337-342
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Dykstra Kevin D.¹^ORCID,Streckfuss Eric²,Liu Min¹,Liu Jian³^ORCID,Yu Younong¹,Wang Ming¹,Kozlowski Joseph A.⁴,Myers Robert W.⁵^ORCID,Buevich Alexei V.⁶^ORCID,Maletic Milana M.¹,Vachal Petr³,Krska Shane W.¹^ORCID

Affiliation:

1. Chemical Capabilities for Accelerating Therapeutics, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

2. Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

3. Screening, Targets and Compound Profiling, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

4. Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

5. Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

6. NMR Structure Elucidation, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00596

Reference27 articles.

1. Practical High-Throughput Experimentation for Chemists

2. The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future

3. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

4. The importance of synthetic chemistry in the pharmaceutical industry

5. Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure–Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H1 Receptor Inverse Agonist

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