Design of First-in-Class Dual EZH2/HDAC Inhibitor: Biochemical Activity and Biological Evaluation in Cancer Cells

Author:

Romanelli Annalisa1,Stazi Giulia1,Fioravanti Rossella1,Zwergel Clemens12ORCID,Di Bello Elisabetta1,Pomella Silvia3,Perrone Clara3,Battistelli Cecilia4,Strippoli Raffaele45,Tripodi Marco45,del Bufalo Donatella6,Rota Rossella3,Trisciuoglio Daniela67,Mai Antonello1ORCID,Valente Sergio1ORCID

Affiliation:

1. Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy

2. Department of Medicine of Precision, University of Campania Luigi Vanvitelli, Via L. De Crecchio 7, 80138 Naples, Italy

3. Department of Oncohematology, Bambino Gesù Children’s Hospital, IRCCS, Viale San Paolo 15, 00146 Rome, Italy

4. Department of Molecular Medicine, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy

5. National Institute for Infectious Diseases L. Spallanzani, IRCCS, Via Portuense 292, 00149 Rome, Italy

6. Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Viale Regina Elena 291,295, 00100 Rome, Italy

7. Institute of Molecular Biology and Pathology, National Research Council (CNR), Via Degli Apuli 4, Rome 00185, Italy

Funder

Associazione Italiana per la Ricerca sul Cancro

Ministero della Salute

National Institutes of Health

Fondazione Umberto Veronesi

Ministero dell'Istruzione, dell'Universit? e della Ricerca

PRIN 2015

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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