Improved Synthesis of [11C]COU and [11C]PHXY, Evaluation of Neurotoxicity, and Imaging of MAOs in Rodent Heart-Reference-Cited by-同舟云学术

Improved Synthesis of [11C]COU and [11C]PHXY, Evaluation of Neurotoxicity, and Imaging of MAOs in Rodent Heart

Published:2020-08-28 Issue:11 Volume:11 Page:2300-2304
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Brooks Allen F.¹^ORCID,Mufarreh Anthony J.¹,Shao Xia¹,Kaur Tanpreet¹,Stauff Jenelle¹,Arteaga Janna¹,Kilbourn Michael R.¹^ORCID,Scott Peter J. H.¹²³^ORCID

Affiliation:

1. Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States

2. Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States

3. Interdepartmental Program in Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States

Funder

National Institute of Neurological Disorders and Stroke

University of Michigan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00419

Reference19 articles.

1. In Vivo Metabolic Trapping Radiotracers for Imaging Monoamine Oxidase-A and -B Enzymatic Activity

2. Deuterium Kinetic Isotope Effect Studies of a Potential in Vivo Metabolic Trapping Agent for Monoamine Oxidase B

3. Design, synthesis, and biological evaluation of novel 4-substituted 1-methyl-1,2,3,6-tetrahydropyridine analogs of MPTP

4. Novel 4-(Aryloxy)tetrahydropyridine Analogs of MPTP as Monoamine Oxidase A and B Substrates

5. Synthesis and MAO-B Substrate Properties of 1-Methyl-4-heteroaryl-1,2,3,6-tetrahydropyridines

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