Novel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants-Reference-Cited by-同舟云学术

Novel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants

Published:2020-03-31 Issue:6 Volume:11 Page:1196-1204
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Zhu Mei¹,Dou Yue²,Ma Ling¹,Dong Biao¹,Zhang Fan²,Zhang Guoning¹,Wang Juxian¹,Zhou Jinming³,Cen Shan¹,Wang Yucheng¹^ORCID

Affiliation:

1. Institute of Medicinal Biotechnology,Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China

2. Department of Pharmacy, Jinzhou Medical University, Jinzhou 121001, China

3. Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, Jinhua 321004, China

Funder

Ministry of Science and Technology of the People's Republic of China

Chinese Academy of Medical Sciences

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00043

Reference37 articles.

1. Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS

2. Improved survival in HIV-infected persons: consequences and perspectives

3. Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study

4. Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV

5. Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants

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