Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5′-Nucleotidase Inhibitors-Reference-Cited by-同舟云学术

Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5′-Nucleotidase Inhibitors

Published:2020-10-29 Issue:12 Volume:11 Page:2397-2405
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Ashraf Abida¹²,Shafiq Zahid¹^ORCID,Khan Jadoon Muhammad Siraj³,Tahir Muhammad Nawaz⁴,Pelletier Julie⁵,Sevigny Jean⁵⁶,Yaqub Muhammad¹,Iqbal Jamshed³^ORCID

Affiliation:

1. Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60000, Pakistan

2. Department of Chemistry, Kuchery Campus, The Women University Multan, Multan, Pakistan

3. Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan

4. Department of Physics, University of Sarghodha, Sarghoda 40100, Pakistan

5. Centre de Recherche du CHU de Québec, Québec, Québec, Canada G1V 4G2

6. Département de Microbiologie-Infectiologie et d’Immunologie, Faculté de Médecine, Université Laval, Québec, Québec, Canada G1V 0A6

Funder

Higher Education Commision, Pakistan

Bahauddin Zakariya University

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00343

Reference40 articles.

1. 5′-Nucleotidase: molecular structure and functional aspects

2. Structure–Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5′-Nucleotidase (CD73) Inhibitors

3. Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form

4. Primary structure of rat liver 5'-nucleotidase deduced from the cDNA. Presence of the COOH-terminal hydrophobic domain for possible post-translational modification by glycophospholipid.

5. 5'-Nucleotidase from the electric ray electric lobe. Primary structure and relation to mammalian and procaryotic enzymes

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