DNA-Model-Based Design and Execution of Some Fused Benzodiazepine Hybrid Payloads for Antibody–Drug Conjugate Modality-Reference-Cited by-同舟云学术

DNA-Model-Based Design and Execution of Some Fused Benzodiazepine Hybrid Payloads for Antibody–Drug Conjugate Modality

Published:2021-02-10 Issue:3 Volume:12 Page:404-412
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Sivaprakasam Prasanna¹^ORCID,McDonald Ivar²,Iwuagwu Christiana²,Chowdari Naidu S.³,Peese Kevin M.²^ORCID,Langley David R.¹,Cheng Heng³^ORCID,Luzung Michael R.⁴,Schmidt Michael A.⁴^ORCID,Zheng Bin⁴^ORCID,Tan Yichen⁴,Cho Patricia⁴,Rakshit Souvik⁵,Lakshminarasimhan Thirumalai⁵,Guturi Sivakrishna⁵,Kanagavel Kishorekumar⁵,Kanusu Umamaheswararao⁵,Niyogi Ankita G.⁵,Sidhar Somprabha⁵,Vaidyanathan Rajappa⁵^ORCID,Eastgate Martin D.⁴^ORCID,Kotapati Srikanth⁶^ORCID,Deshpande Madhura⁶,Pan Chin⁷,Cardarelli Pina M.⁷,Xie Chunshan⁸,Rao Chetana⁶,Holder Patrick⁶,Sarma Ganapathy⁶,Vite Gregory⁹,Gangwar Sanjeev³

Affiliation:

1. Computer-Aided Drug Design, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States

2. Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States

3. Discovery Chemistry, Bristol-Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States

4. Chemical and Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States

5. Chemical Development and API Supply, Biocon Bristol-Myers Squibb Research and Development Center, Biocon Park, Jigani Link Road, Bommasandra IV, Bangalore 560099, India

6. Discovery Biotherapeutics, Bristol-Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States

7. Cell Biology and Pharmacology, Bristol-Myers Squibb Research & Development, 700 Bay Road, Redwood City, California 94063, United States

8. Lead Discovery and Optimization, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08543, United States

9. Discovery Chemistry, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08543, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00578

Reference26 articles.

1. Antibody–drug conjugates for cancer

2. Antibody-Drug Conjugates as Cancer Therapeutics: Past, Present, and Future

3. Antibody-drug conjugates (ADCs): Potent biopharmaceuticals to target solid and hematological cancers- an overview

4. An overview of antibody–drug conjugates in oncological practice

5. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy

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