Thiophene-Pyrazolourea Derivatives as Potent, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors-Reference-Cited by-同舟云学术

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Thiophene-Pyrazolourea Derivatives as Potent, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors

Published:2020-12-13 Issue:1 Volume:12 Page:24-29
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Feng Yangbo¹^ORCID,Park HaJeung²,Bauer Luke³^ORCID,Ryu Jae Cheon³,Yoon Sung OK³

Affiliation:

1. Reaction Biology Corporation, One Great Valley Parkway, Malvern, Pennsylvania 19355, United States

2. Crystallography Core Facility, Scripps Florida, TSRI, 130 Scripps Way, Jupiter, Florida 33458, United States

3. Department of Biological Chemistry & Pharmacology, Ohio State University College of Medicine, Columbus, Ohio 43210, United States

Funder

Alzheimer's Drug Discovery Foundation

National Institute on Aging

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00533

Reference26 articles.

1. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

2. Selective interaction of JNK protein kinase isoforms with transcription factors.

3. Nocodazole-induced p53-dependent c-Jun N-terminal Kinase Activation Reduces Apoptosis in Human Colon Carcinoma HCT116 Cells

4. JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides

5. MiR-335-5p Inhibits β-Amyloid (Aβ) Accumulation to Attenuate Cognitive Deficits Through Targeting c-jun-N-terminal Kinase 3 in Alzheimer’s Disease

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4. The Role of the Dysregulated JNK Signaling Pathway in the Pathogenesis of Human Diseases and Its Potential Therapeutic Strategies: A Comprehensive Review;Biomolecules;2024-02-19

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