The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin-Reference-Cited by-同舟云学术

The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin

Published:2021-02-09 Issue:3 Volume:12 Page:426-432
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Lam van Thuy Van¹,Heindl Miriam Ruth²,Schlutt Christine¹,Böttcher-Friebertshäuser Eva²,Bartenschlager Ralf³,Klebe Gerhard¹^ORCID,Brandstetter Hans⁴^ORCID,Dahms Sven O.¹⁴,Steinmetzer Torsten¹^ORCID

Affiliation:

1. Institute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 6, 35032 Marburg, Germany

2. Institute of Virology, Philipps University, Hans-Meerwein-Strasse 2, 35043 Marburg, Germany

3. Department of Infectious Diseases, Molecular Virology, Heidelberg University and German Center for Infection Research, Heidelberg Partner Site, Im Neuenheimer Feld 344, 69120 Heidelberg, Germany

4. Department of Biosciences, University of Salzburg, Billrothstrasse 11, 5020 Salzburg, Austria

Funder

Austrian Science Fund

LOEWE Center DRUID

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00651

Reference32 articles.

1. Furin at the cutting edge: From protein traffic to embryogenesis and disease