<i>Mycobacterium tuberculosis</i> PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas-Reference-Cited by-同舟云学术

Mycobacterium tuberculosis PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas

Published:2023-06-26 Issue:7 Volume:14 Page:970-976
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Ottavi Samantha¹^ORCID,Li Kelin¹,Cacioppo Jackson G.²^ORCID,Perkowski Andrew J.¹^ORCID,Ramesh Remya¹,Gold Ben S.³^ORCID,Ling Yan³,Roberts Julia³,Singh Amrita³^ORCID,Zhang David³,Mosior John⁴,Goullieux Laurent⁵,Roubert Christine⁵,Bacqué Eric⁵,Sacchettini James C.⁴^ORCID,Nathan Carl F.³,Aubé Jeffrey¹²^ORCID

Affiliation:

1. Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

2. Department of Chemistry, UNC College of Arts and Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

3. Department of Microbiology & Immunology, Weill Cornell Medicine, New York, New York 10065, United States

4. Departments of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, Texas 77843, United States

5. Evotec ID (Lyon), SAS 40 Avenue Tony Garnier, 69001 Lyon, France

Funder

National Institute of Allergy and Infectious Diseases

Hearst Foundations

National Institute of General Medical Sciences

TB Drug Accelerator of the Bill and Melinda Gates Foundation

Abby and Howard P. Milstein Program in Chemical Biology and Translational Medicine

ACS Division of Medicinal Chemistry

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00162

Reference22 articles.

1. World Health Organization Global tuberculosis report 2022; 27 October 2022, https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022.

2. Drug Resistance Mechanisms in Mycobacterium tuberculosis

3. The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life

4. 4′-Phosphopantetheinyl Transferase PptT, a New Drug Target Required for Mycobacterium tuberculosis Growth and Persistence In Vivo

5. Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

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