Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library
Author:
Affiliation:
1. Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia
2. Department of Chemistry “G. Ciamician”, University of Bologna, 40126 Bologna, Italy
Funder
European Regional Development Fund
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00403
Reference22 articles.
1. World Malaria Report 2018; World Health Organization: Geneva, 2016. https://www.who.int/publications/i/item/9789241565653.
2. Drug-resistant malaria − an insight
3. New medicines to improve control and contribute to the eradication of malaria
4. MMV’s Pipeline of Antimalarial Drugs; Medicines for Malaria Venture, 2023. https://www.mmv.org/mmv-pipeline-antimalarial-drugs (accessed 02-02-2023).
5. Aminoacyl-tRNA synthetases as therapeutic targets
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