Exploring Scaffold Hopping for Novel 2-(Quinolin-4-yloxy)acetamides with Enhanced Antimycobacterial Activity

Author:

Borsoi Ana Flávia12,Silva Ramos Alessandro1,Sperotto Nathalia1,Abbadi Bruno Lopes1,Souza Macchi Hopf Fernanda13,da Silva Dadda Adilio1,Scheibler Rambo Raoní1,Neves Muniz Mauro1,Delgado Paz Josiane1,Silveira Grams Estevão13,Fries da Silva Fernanda13,Pissinate Kenia1,Galina Luiza1,Calle González Laura13,Silva Duarte Lovaine1,Alberton Perelló Marcia1,de Matos Czeczot Alexia13,Bizarro Cristiano Valim13ORCID,Basso Luiz Augusto123ORCID,Machado Pablo123ORCID

Affiliation:

1. Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900 Porto Alegre, Rio Grande do Sul, Brazil

2. Programa de Pós-Graduação em Medicina e Ciências da Saúde, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900 Porto Alegre, Rio Grande do Sul, Brazil

3. Programa de Pós-Graduação em Biologia Celular e Molecular, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900 Porto Alegre, Rio Grande do Sul, Brazil

Funder

Instituto Nacional de Ci?ncia e Tecnologia em Tuberculose

Publisher

American Chemical Society (ACS)

Reference24 articles.

1. Global tuberculosis report 2023. World Health Organization. Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2023, (accessed in December 2023).

2. WHO Report: Years of Progress in Global Tuberculosis Upset by COVID-19 Pandemic

3. The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis

4. Delamanid for Multidrug-Resistant Pulmonary Tuberculosis

5. A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

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