Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration-Reference-Cited by-同舟云学术

Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration

Published:2023-11-30 Issue:12 Volume:14 Page:1746-1753
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Fnaiche Ahmed¹,Chan Hwai-Chien¹,Paquin Alexis¹,González Suárez Narjara¹,Vu Victoria²,Li Fengling²,Allali-Hassani Abdellah²,Cao Michelle Ada²³,Szewczyk Magdalena M.²,Bolotokova Albina²,Allemand Frédéric⁴,Gelin Muriel⁴,Barsyte-Lovejoy Dalia²,Santhakumar Vijayaratnam²^ORCID,Vedadi Masoud³⁵^ORCID,Guichou Jean-François⁴,Annabi Borhane¹,Gagnon Alexandre¹^ORCID

Affiliation:

1. Département de Chimie, Université du Québec à Montréal, C.P. 8888, Succursale Centre-Ville, Montréal, Québec H3C 3P8, Canada

2. Structural Genomics Consortium, 101 College Street, Toronto, Ontario M5G 1L7, Canada

3. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

4. Centre de Biologie Structurale, CNRS, INSERM, Univ. Montpellier, 34090 Montpellier, France

5. Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada

Funder

Agence Nationale de la Recherche

Universit? du Qu?bec ? Montr?al

Structural Genomics Consortium

Natural Sciences and Engineering Research Council of Canada

Fonds de recherche du Qu?bec - Nature et technologies

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00386

Reference50 articles.

1. Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

2. The Hippo pathway in organ development, homeostasis, and regeneration

3. Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

4. Hippo signaling: growth control and beyond

5. The Biology of YAP/TAZ: Hippo Signaling and Beyond

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