TMPRSS2 Inhibitor Discovery Facilitated through an <i>In Silico</i> and Biochemical Screening Platform-Reference-Cited by-同舟云学术

TMPRSS2 Inhibitor Discovery Facilitated through an In Silico and Biochemical Screening Platform

Published:2023-05-30 Issue:6 Volume:14 Page:860-866
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Peiffer Amanda L.¹²,Garlick Julie M.¹³,Wu Yujin³,Wotring Jesse W.⁴,Arora Sahil³,Harmata Alexander S.³,Bochar Daniel A.³,Stephenson Corey J.³^ORCID,Soellner Matthew B.²³^ORCID,Sexton Jonathan Z.⁴⁵,Brooks Charles L.²³⁶^ORCID,Mapp Anna K.¹²³^ORCID

Affiliation:

1. Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48019, United States

2. Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109, United States

3. Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States

4. Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States

5. University of Michigan Medical School, Ann Arbor, Michigan 48109, United States

6. Department of Biophysics, University of Michigan, Ann Arbor, Michigan 48109, United States

Funder

University of Michigan

National Institute of General Medical Sciences

Klatskin-Sutker Discovery Fund

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00035

Reference39 articles.

1. A tale of two antiviral targets — and the COVID-19 drugs that bind them

2. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

3. Coronavirus biology and replication: implications for SARS-CoV-2

4. Phenotypic Analysis of Mice Lacking the Tmprss2 -Encoded Protease

5. TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?

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