DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2

DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2–p53 Inhibitor

Published:2023-05-05 Issue:6 Volume:14 Page:820-826
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Silvestri Anthony P.¹^ORCID,Zhang Qi²,Ping Yan²,Muir Erik W.¹,Zhao Jingsi²,Chakka Sai Kumar¹,Wang Gaonan²,Bray Walter M.¹,Chen Wenhua²,Fribourgh Jennifer L.¹,Tripathi Sarvind³^ORCID,He Yunyun²,Rubin Seth M.³^ORCID,Satz Alexander L.⁴^ORCID,Pye Cameron R.¹,Kuai Letian⁵,Su Wenji²^ORCID,Schwochert Joshua A.¹

Affiliation:

1. Unnatural Products, Inc., 2161 Delaware Ave. Suite A, Santa Cruz, California 95060, United States

2. WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China

3. Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, United States

4. WuXi AppTec, Am Klopferspitz 19a, 82152 Martinsried, Germany

5. WuXi AppTec, 55 Cambridge Parkway, 8th Floor, Cambridge, Massachusetts 02142, United States

Funder

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00117

Reference28 articles.

1. Constrained peptides' time to shine?

2. Cyclic peptide therapeutics: past, present and future

3. Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges

4. Exploring sequence space: harnessing chemical and biological diversity towards new peptide leads

5. Ultra-large chemical libraries for the discovery of high-affinity peptide binders

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