Identification of Spiro[chromene-2,4′-piperidine]s as Potent, Selective, and G<sub>q</sub>-Biased 5-HT<sub>2C</sub> Receptor Partial Agonists-Reference-Cited by-同舟云学术

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Identification of Spiro[chromene-2,4′-piperidine]s as Potent, Selective, and G_q-Biased 5-HT_2C Receptor Partial Agonists

Published:2023-12-18 Issue:1 Volume:15 Page:99-106
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Jiang Guangqian¹,Zhang Bingjie²³,Zhang Xiaoya¹,Chen Fan¹,Qin Wangzhi¹,Chen Jing-Lei¹,Tian Sheng¹,Shui Wenqing²³^ORCID,Ye Na¹^ORCID

Affiliation:

1. Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China

2. iHuman Institute, ShanghaiTech University, Shanghai 201210, China

3. School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China

Funder

Hui-Chun Chin and Tsung-Dao Lee Chinese Undergraduate Research Endowment

National Natural Science Foundation of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

Natural Science Foundation of the Jiangsu Higher Education Institutes

Shanghai Sailing Program

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00454

Reference40 articles.

1. Biased ligands at G-protein-coupled receptors: promise and progress

2. Catalytic activation of β-arrestin by GPCRs

3. β−Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives

4. Visualization of arrestin recruitment by a G-protein-coupled receptor

5. First Clinical Experience With TRV130: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers

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