Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator
Author:
Affiliation:
1. External Discovery Chemistry, Merck & Co., Inc, Boston, Massachusetts 02115, United States
Funder
Merck Sharp and Dohme
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00210
Reference36 articles.
1. Glutamate: A Neurotransmitter in Mammalian Brain
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1. Discovery of 6,7-Dihydropyrazolo[1,5-a]pyrazin-4(5H)-one Derivatives as mGluR2 Negative Allosteric Modulators with In Vivo Activity in a Rodent’s Model of Cognition;Journal of Medicinal Chemistry;2024-08-29
2. Adaptive Changes in Group 2 Metabotropic Glutamate Receptors Underlie the Deficit in Recognition Memory Induced by Methamphetamine in Mice;eneuro;2024-07-05
3. Design and Synthesis of MK-8768: a Potent and Selective mGluR2 Negative Allosteric Modulator;Synfacts;2023-09-14
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