Discovery of Pyrrolo[2,3-<i>c</i>]pyridines as Potent and Reversible LSD1 Inhibitors-Reference-Cited by-同舟云学术

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Discovery of Pyrrolo[2,3-c]pyridines as Potent and Reversible LSD1 Inhibitors

Published:2023-09-21 Issue:10 Volume:14 Page:1389-1395
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Zheng Canhui¹^ORCID,Rej Rohan Kalyan¹^ORCID,Wang Mi¹,Huang Liyue¹,Fernandez-Salas Ester¹²,Yang Chao-Yie¹^ORCID,Wang Shaomeng¹³⁴²^ORCID

Affiliation:

1. Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States

2. Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States

3. Department of Pharmacology, Medical School, University of Michigan, Ann Arbor, Michigan 48109, United States

4. Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States

Funder

National Cancer Institute

Ascentage Pharma

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00292

Reference31 articles.

1. Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1

2. The histone LSD1 demethylase in stemness and cancer transcription programs

3. Chromatin remodeling and cancer, part I: covalent histone modifications

4. C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4

5. KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease

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