A Novel 7<i>H</i>-[1,2,4]Triazolo[3,4-<i>b</i>]thiadiazine-based Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Directed toward Treatment of Cystic Fibrosis-Reference-Cited by-同舟云学术

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A Novel 7H-[1,2,4]Triazolo[3,4-b]thiadiazine-based Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Directed toward Treatment of Cystic Fibrosis

Published:2023-09-20 Issue:10 Volume:14 Page:1338-1343
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Rab Andras¹,Yang Xun²,Tracy William F.²^ORCID,Hong Jeong S.¹,Joshi Disha¹,Manfredi Candela¹,Ponnaluri Sadhana S.¹,Kolykhalov Alexander A.³,Qui Min⁴⁵,Fu Haian⁴⁵,Du Yuhong⁴⁵,Davies Huw M. L.²^ORCID,Sorscher Eric J.¹^ORCID

Affiliation:

1. Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, United States

2. Department of Chemistry, Emory University, 1515 Dickey Dr., Atlanta, Georgia 30329, United States

3. Emory Institute for Drug Development, Atlanta, Georgia 30322, United States

4. Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia 30322, United States

5. Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, Georgia 30322, United States

Funder

Cystic Fibrosis Foundation

Wish for Wendy Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00155

Reference30 articles.

1. Identification of the Cystic Fibrosis Gene: Genetic Analysis

2. Emerging Treatments in Cystic Fibrosis

3. US CF Foundation CFTR2 Database. cftr2.org (accessed February 3, 2023).

4. Cystic Fibrosis

5. Making precision medicine personal for cystic fibrosis

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